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张冬卉

作者:  发布时间:2024-02-24  阅读次数:

一、基本信息

张冬卉,博士,教授,博士生导师

电子邮件:dongh.zhang(AT)hubu.edu.cn

研究领域:干细胞生物学、组织工程、微器官芯片构建

研究方向:

1.心肌病新型诊疗方案开发:

针对遗传性心肌病,从心肌细胞骨架、代谢、生理等多方面研究早期疾病发生后的细胞生物学事件及发病机制,并通过进一步的心肌细胞组织模型,心肌组织结构与功能互作的调控网络,寻找疾病发生时的潜在干预靶点,开发靶向性干预方案。

2.心肌损伤过程中的心肌保护策略开发:

研究心肌的缺氧、代谢及炎症损伤过程,并建立相应的心肌微组织研究模型,研究心肌损伤病理发展过程中的分子调控-组织重塑-功能重建过程,开发病程阶段性诊断标志物体系、挖掘干预靶点、发展包括基因治疗和细胞治疗在内的新型治疗方案。

3.瓣膜钙化的模拟与疗法开发:

该方向旨在建立人iPS细胞库,定向诱导分化为VECsVICs,组学分析iPS源性瓣膜细胞异质性;探讨遗传因素导致瓣膜钙化的机制,同时建立3D水凝胶的组织钙化模型,研究遗传因素、生化刺激、力学信号等导致VICs钙化作用机制,用于疾病药物的筛选和致病机理的探索。

4.微器官体外生理系统开发:

本项目旨在开发各向异性的微组织器官模型,用于研究力学因素在细胞命运编程、组织功能重塑的作用。开发新型微器官体外模型及生理病理微生境构建方案及检测方案,用于标准化、规模化研究组织发育和病理演化。

二、教育背景

2005–2010  北京大学3344体育会员生物技术专业,理学博士

2001–2005  西安交通大学生物工程专业,工学学士

三、工作经历

2017至今     3344体育会员干细胞与组织工程实验室,教授,博士生导师

2013–2017  哈佛医学院波士顿儿童医院,博士后,合作导师:William Pu教授

2011–2013  杜克大学生物医学工程系,博士后,合作导师:Nenad Bursac 教授

四、科研项目

1. 国家重点研发计划(2018YFA0109100):重编程化学小分子诱导心肌细胞去分化的分子机制及其在心脏再生修复中的应用;经费170万;2018.07–2022.12,项目骨干国家自然科学基金面上项目,基于人工程化心肌组织模型研究缺血性心脏病致病机理,2022/01-2025.12 58万元,主持

2. 横向技术开发合作项目,人多能干细胞衍生心肌缓解小动物心衰,2022/01-2024.0197万元,主持

3. 国家级人才项目,2021/12-2026.12,主持

4. 科技部重点研发计划,iPS源性瓣膜细胞钙化模型建立及应用,2021.12-2026.12277万元(个人经费),主持

5. 国家自然科学基金面上项目,利用人心脏微器官研究儿茶酚胺敏感型心律失常发病机制,2019/01-2022/1259万元,主持

6. 湖北省自然科学基金杰出青年人才项目,利用人诱导多能干细胞构建人胰岛-心肌联合微器官芯片,2019/01-2021/1210万元,主持

7. 科技部重点研发计划,重编程化学小分子诱导心肌细胞区分化的分子机制及其在心脏再生修复中的应用,2018/07 - 2022/12170万元

8. 国家自然科学基金应急项目,TFAM抑制导致的线粒体损伤对人心肌细胞扩增及成熟影响的研究,2018/01-2018/1215万元,主持

五、代表著作(#共同第一作者,*通讯作者)

1. Cai, L., Wang, R., Zhang, D*. (2023). Cardiac Disease Modeling with Engineered Heart Tissue. In: Kuehn, M.H., Zhu, W. (eds) Human iPSC-derived Disease Models for Drug Discovery. Handbook of Experimental Pharmacology, vol 281. Springer, Cham.

2. Li T, Jin Y, Liu R, Hua Y, Zhou K, Luo S*, Li Y*, Zhang D*. A novel compound heterozygous variant in ALPK3 induced hypertrophic cardiomyopathy: a case report. Front Cardiovasc Med. 2023, 15;10:1212417.

3. Liu Y, Zhang D*, Yin D*. Pathophysiological Effects of Various Interleukins on Primary Cell Types in Common Heart Disease. Int J Mol Sci. 2023, 30;24(7):6497.

4. Li L, Wan Z, Wang R, Zhao Y, Ye Y, Yang P, Qi Y, Jiang W*, Cai L*, Zhang D*. Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells. Cell Discov. 2022 Oct 11;8(1):105.

5. Yang,Yage Nie,Yinghan Wang,Zhan-peng Huang,Guanzheng Luo,Zhongyan Chen, Donghui Zhang*, Nan Cao*.  Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues[J]. Advanced Science, 2022: 2203388.

6. Jianqing Lin, Xiaolong Cai, Xiaoyan Zhang, Jia Wang, Donghui Zhang*, Nan Cao*.  Spike-based adenovirus vectored COVID-19 vaccine does not aggravate heart damage after ischemic injury in mice[J]. Communications biology, 2022, 5(1): 1-11.

7. Junmei Wang,Qian Liu,Jixing Gong,Zhongjun Wan,Jinping Zhou,Chunyu Chang*, Donghui Zhang*. Micropatterned Hydrogels with Highly Ordered Cellulose Nanocrystals for Visually Monitoring Cardiomyocytes[J]. Small, 2022: 2202235.

8. Qi Y, Ye Y, Wang R, Yu S, Zhang Y, Lv J, Jin W, Xia S, Jiang W*, Li Y*, Zhang D*. Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response. Redox Biology. 2022.Jan. DOI: 10.1016/j.redox.2022.102248.

9. Zheng R, Geng T, Wu D, Zhang T, He H, Du H, Zhang D*, Miao Y*, Jiang W*. Derivation of feeder-free human extended pluripotent stem cells. Stem Cell Reports. 2021 July 7,16:1686-1696.

10. Li J, Zhang Y, Zhang D*, Li Y*. The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction. Front Cardiovasc Med. 2021 May 10;8:684348.

11. Meng X, Xing Y, Li J, Deng C, Li Y, Ren X*, Zhang D*. Rebuilding the Vascular Network: In vivo and in vitro Approaches. Front Cell Dev Biol. 2021 Apr 21;9:639299.

12. Lu P, Li M, Zhang D*, Jiang W*. Lnc-ing pluripotency maintenance and early differentiation in human pluripotent stem cells. FASEB J. 2021 Apr;35(4):e21438.

13. Liao H, Qi Y, Ye Y, Yue P, Zhang D*, Li Y*. Mechanotranduction Pathways in the Regulation of Mitochondrial Homeostasis in Cardiomyocytes. Front Cell Dev Biol. 2021 Jan 21;8:625089.

14. Yue P, Xia S, Wu G, Liu L, Zhou K, Liao H, Li J, Zheng X, Guo Y, Hua Y, Zhang D*, Li Y*. Attenuation of Cardiomyocyte Hypertrophy via Depletion Myh7 using CASAAV. Cardiovasc Toxicol. 2021 Mar;21(3):255-264.

15. Xia S, Wang X, Yue P, Li Y*, Zhang D*. Establishment of induced pluripotent stem cell lines from a family of an ARVC patient receiving heart transplantation in infant age carrying compound heterozygous mutations in DSP gene. Stem Cell Res. 2020 Oct;48:101977.

16. Liu L, Zhang D*, Li Y*. LncRNAs in cardiac hypertrophy: From basic science to clinical application. J Cell Mol Med. 2020 Oct;24(20):11638-11645.

17. Park SJ#, Zhang D#, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT*, Parker KK*. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 Jul 30;140(5):390-404.

18. Yang X, Li L, Xiao L*, Zhang D*. Recycle the dental fairy's package: overview of dental pulp stem cells. Stem Cell Res Ther. 2018 Dec 13;9(1):347.

19. Zhang D, Pu WT*. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 Jul;15(7):383-384.

20. Zhang D#, Li Y#, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT*. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 Jan 5;122(1):74-87.

21. Li Y, Zhang D*. Artificial Cardiac Muscle with or without the Use of Scaffolds. Biomed Res Int. 2017;2017:8473465.

22. Zhang D*, Jiang W*. From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 2015;65(5): 468-475.

23. Zhang D, Shadrin IY, Lam J, Xian HQ, Snodgrass HR, Bursac N*. Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials. 2013 Jul;34(23):5813-20.

24. Zhu FF#, Zhang PB#, Zhang DH#, Sui X, Yin M, Xiang TT, Shi Y, Ding MX, Deng H*. Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells. Diabetologia. 2011 Sep;54(9):2325-36.

25. Zhang D, Jiang W, Shi Y, Deng H*. Generation of pancreatic islet cells from human embryonic stem cells. Sci China C Life Sci. 2009 Jul;52(7):615-21.

26. Zhang D#, Jiang W#, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H*. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 2009 Apr;19(4):429-38. (Cover paper and highlight paper)

27. 刘倩, 姚雨峰, 蔡琳*, 张冬卉*. 糖尿病心肌病体内与体外模型研究进展.中国比较医学杂志, 2022.

六、专利

1. 张冬卉, 李俐, 蔡琳, 万忠均, 汪如香; 一种拓展性多能干细胞诱导分化为心肌细胞的方法及应用, 2022-10-11, 中国。

2. 张冬卉, 杨鹏程, 龚吉星; 一种人工心肌组织纤维化模型、制备方法、制备装置及其应用,2022-03-08,中国。

七、招贤纳士

1. 本实验室招助研、讲师及副教授。有细胞生物学、医学、生理学、材料学或表面化学背景,发表过SCI论文,具有合作精神。可将简历发送至dongh.zhang@hubu.edu.cn,待遇面议。

2. 本实验室长期招收有探索精神、动手能力强并踏实细致的本科生,数学功底强,

 

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